Extended Data Fig. 9: Loss of Qpctl remodels the tumor myeloid compartments. | Nature Immunology

Extended Data Fig. 9: Loss of Qpctl remodels the tumor myeloid compartments.

From: Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

Extended Data Fig. 9

a,b,c,d,e,f,g,h,i,j, Qpctl–/– and Qpctl+/+ littermates were inoculated with Qpctl–/– or Qpctl+/+ LL/2 tumors, respectively. On day 14 after tumor inoculation, tumors were excised and processed for single-cell RNA-seq. a, Heatmap showing normalized expression of top 10 expressed genes in each Monocyte/Macrophage/DC cluster. b, Dot plots of selected markers in monocyte populations. Dot size indicates proportion of cells in each cluster expressing a gene, color shading indicates the relative level of gene expression. c, Violin plot representing Ly6c2 expression across Monocyte/Macrophage/DC clusters. d, Violin plot representing the expression of a blood Ly6C+ monocyte signature across Monocyte/Macrophage/DC clusters. e, Dot plots of selected markers in dendritic cell populations. Dot size indicates proportion of cells in each cluster expressing a gene, color shading indicates the relative levels of gene expression. f, Violin plots representing the expression of indicated genes across macrophage clusters. g, Similarity score between the Mac_Ki67 cluster and the other Monocyte/Macrophage/DC clusters. h,i, Violin plots representing the expression of indicated gene signatures across macrophage clusters. j, Violin plot representing Csf1r expression across macrophage clusters.

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