Extended Data Fig. 7: Impact of myeloid cells on RNA-LPX induced systemic cytokine responses in vivo. | Nature Immunology

Extended Data Fig. 7: Impact of myeloid cells on RNA-LPX induced systemic cytokine responses in vivo.

From: IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

Extended Data Fig. 7

a, b, Systemic cytokine response in Ly6G-depleted wildtype (n = 8) and Il1rn-/- mice (n = 7) following RNA-LPX administration in vivo. e, Expression of decoy receptor IL-1R2 on splenic neutrophils 24 hr post-RNA-LPX (n = 7). f, g, Systemic cytokine response in Flt3L-pretreated wildtype (n = 6) and Il1rn-/- mice (n = 6) following RNA-LPX administration in vivo. The data are representative of two independent experiments with biologically independent samples. Significance was determined by using one-way ANOVA and Tukey’s multiple comparisons test (b, e) or by unpaired two-tailed Student’s t-test (c). Data presented as median.

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