Extended Data Fig. 8: IL-1ra downregulates the response to different TLR stimuli in vivo.
From: IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
Core body temperature (a, c) and serum proteins (b, d) in wildtype (n = 7) and Il1rn-/- mice (n = 7) after systemic administration of HKLM or ODN1826. Significance was determined using two-way repeated measures ANOVA and Sidak’s multiple comparisons test (a, c) or one-way ANOVA and Dunnett’s multiple comparisons test (b, d). Data presented as median (b, d), otherwise mean ± SEM.
