Extended Data Fig. 2: Intravenous administration of RNA-LPX induces secretion of both IL-1β and IL-1α in C57BL/6 mice.
From: IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
a-g, IL-1β and IL-1α measured 6 hours after IV injection of RNA-LPX in serum (b, n = 9) and in splenic myeloid cell subsets (n = 7) (c, d, e, f, g). The data are pooled from two independent experiments with biologically independent samples (b-f). Significance was determined by using unpaired two-tailed Student’s t-test (b) or one-way ANOVA and Tukey’s multiple comparisons test (d, f). Data presented as mean ± SEM (g), otherwise median. Rpϕ, red pulp macrophage; MMϕ, marginal metallophilic macrophage; MZϕ, marginal zone macrophage.
