Extended Data Fig. 5: Piericidin A inhibits mitochondrial complex I to modulate LPS-dependent mRNA expression.
From: Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
a) Principal component analysis of RNASeq data on WT and NDI1 BMDMs treated, or not, with LPS (100 ng/mL) for 4 hours. Each dot represents RNASeq data from a single sample. (N = 5 for each treatment). b) Principal component analysis of RNASeq data on WT and NDI1 BMDMs treated with LPS (100 ng/mL) for 4 hours, with or without piericidin A (500 nM). Each dot represents RNASeq from a single sample. (N = 5 for each treatment).
