Extended Data Fig. 10: An updated model for NLRP3 inflammasome assembly and activation. | Nature Immunology

Extended Data Fig. 10: An updated model for NLRP3 inflammasome assembly and activation.

From: NLRP3 licenses NLRP11 for inflammasome activation in human macrophages

Extended Data Fig. 10

Human NLRP11 binds ASC by PYRIN domain (PYD)-PYD interaction and to NLRP3 through its NACHT-LRR region, thereby acting as a scaffold for bridging ASC and NLRP3, which facilitates efficient oligomerization of NLRP3 and consequently, enables caspase-1 activation, IL-1β and IL-18 release and pyroptosis by promoting the polymerization of ASC.

Back to article page