Fig. 2: SARS-CoV-2 spike-directed neutralizing antibodies.
From: The humoral response and antibodies against SARS-CoV-2 infection
a, Spike protein of SARS-CoV-2. Top, schematic diagram of the domain organization. SD1, subdomain 1; SD2, subdomain 2; FP, fusion peptide; HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain. S1/S2 and S2 are two protease cleavage sites. Left, closed state of the spike trimer with three down RBDs; right, open state of the spike trimer with two down RBDs and one up RBD. The spike is presented as a gray cartoon, with the RBD highlighted in cyan. The structures were published in ref. 97. b, RBD-directed neutralizing antibodies. For each antibody community (RBD-1 to RBD-7), the footprint of a representative antibody on the RBD is shown. The highly conserved N343 glycosylation site on the outer face is colored in deep blue. The RBM is outlined in light coral. See Table 1 for corresponding references. c, NTD-directed neutralizing antibodies. For each antibody community (NTD-1 to NTD-3), a representative complex structure of the spike trimer bound by the antibody is shown. The spike trimer and antibody are both presented as surface, with RBD colored in cyan, NTD in purple and S2 in gray.
