Extended Data Fig. 7: Cross-tissue analysis of fibroblast scRNA-seq datasets.
From: ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts
a, b, Mouse perturbed-state fibroblasts atlas4 and the expression of Ets1, Tnfsf11, Mmp13 and Mmp3 in the identified clusters (a) colored by Adamdec1 logcounts and in the fibroblast cells across diseases (b) (https://www.fibroxplorer.com/home). c, Dot plot showing the expression of ETS1, TNFSF11, MMP3 and MMP13 in ulcerative colitis (UC)-associated stromal cells and healthy controls (SCP259). d, Dot plot showing the expression of ETS1, TNFSF11, MMP3 and MMP13 in stromal cells of tumor tissues and adjacent normal colon tissues of CRC patients (GSE178341). e, Dot plot showing the expression of ETS1, TNFSF11, MMP3 and MMP13 across CRC-associated fibroblast clusters (GSE178341). f, Expression levels of TNFSF11, MMP13, MMP3 in TCGA datasets of CRC patients. Groups were split by the expression levels of ETS1 (top third ETS1high, n = 84; bottom third ETS1low, n = 84). Box plots (center: median; limits: upper 75th percentile, lower: 25th percentile); whiskers were drawn independently above and below the box and extended to the maximum and minimum values (1.5*interquartile range, points were outliers). P values were calculated by two-tailed Student’s t-test.
