Extended Data Fig. 3: Trmt61a KO T cells failed to induce adoptive transfer colitis.
From: tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
a. Representative flow cytometry gating strategy for thymocyte. b. Representative flow cytometry gating strategy for CD4+ T cell and CD8+ T cell in spleen or lymph nodes. c. Representative image of the colons from Rag2−/− mice receiving WT or Trmt61a-KO naïve CD4+ T cells 12 weeks post-transfer. Scale bars, 1 cm. d. The length of colons from Rag2−/− mice receiving WT or Trmt61a-KO naïve CD4+ T cells 12 weeks post-transfer. Error bars represent mean ± s.e.m., n = 8 biologically independent animals. *** P = 0.0002; two-tailed, unpaired t-test.
