Extended Data Fig. 4: Bulk RNA-Seq analysis of NDNs, LDNs and monocytes.
From: Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress
a, b. Principal-component analysis (PCA) plots of bulk RNA-Seq datasets of NDNs, LDNs and monocytes isolated from PB of healthy controls (n = 19), G-CSF-treated donors (n = 17), HSC-T (n = 8), PDAC (n = 15) and IPMN (n = 14) patients, as well as of neutrophil differentiation intermediates from BM of healthy donors (n = 3) and HSC-T patients (n = 7). Samples are colored based on cell type (a) or stress condition (b), as indicated by the legends. Filled area plot on the left show the frequency of neutrophil precursors (pre), immature (imm) and mature (mat) neutrophils for the corresponding NDNs and LDNs samples along PC2. c. PCA plots of bulk RNA-Seq datasets of NDNs, LDNs or monocytes. Colors represent stress condition, while shapes reflect the tissue of origin (PB circle; BM triangle), as indicated in the legend.
