Extended Data Fig. 7: Mass cytometry analysis of cell compositions in control and CRS patients.
From: Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
a, tSNE plot displaying clustering of immune and nonimmune cells pooled from 50,000 cellular events in each group and equally divided among each individual (3 healthy controls, 3 CRSsNP patients, 3 neCRSwNP patients, and 5 eCRSwNP patients). b, tSNE plots showing expression of marker genes for cell subsets defined in the panel a. c, tSNE plot displaying clustering of myeloid cells from panel a. d, tSNE plots showing expression of marker genes for myeloid subsets defined in the panel c. e, tSNE plot displaying clustering of T cells and NK cells from panel a. f, tSNE plots showing expression of marker genes for T cell and NK cell subsets defined in the panel e. g, Box and whisker plots showing the proportion of the CX3CR1+ and CD209+ tissue-resident macrophages in all macrophages and the proportion of the CD8+ TRM in all T cells with plot center, box and whiskers corresponding to median, IQR and 1.5 × IQR, respectively. Unpaired two-sided t-tests. *P < 0.05. h, Violin plots showing the expression levels of CD1b in cDC2s among control and CRS subtypes. Unpaired two-sided t-tests. *P < 0.05, **P < 0.01, ****P < 0.0001. All panels depict the same number of individuals described in panel a.
