Extended Data Fig. 8: Expression of ALOX15 in human nasal samples.
From: Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
a, Representative immunofluorescent assay was performed with anti-ALOX15 (green) and anti-CD3 (red) for T cells, anti-CD20 (red) for B cells, anti-CD138 (red) for plasma cells, anti-EMBP (red) for eosinophils, anti-CD11c (red) for DCs, and anti-Tryptase (red) for mast cells (n = 4 for each group). Scale bars, 10 µm. Results are presented as Mean ± SEM in bar plots. Unpaired two-sided t-tests. *P < 0.05, **P < 0.01. b, The Pearson correlation analysis (two-sided) between ALOX15 expression and four clinical parameters evaluating CRS severity, including tissue eosinophil count/HPF, serum total IgE level, SNOT-22 score, and CT Lund-MacKay score. The expression levels of ALOX15 measured by ELISA in surgical nasal samples of an independent cohort of patients with CRSsNP (n = 27), neCRSwNP (n = 28), and eCRSwNP (n = 32). This figure supports Fig. 6.
