Extended Data Fig. 3: Compositions and pathologic vascular functions of smooth muscle cells and endothelial cells in control and CRS patients.

a, tSNE plots displaying 1,953 smooth muscle cells from 21 individuals (5 healthy controls, 5 CRSsNP, 5 neCRSwNP, and 6 eCRSwNP patients) separated into 4 subsets (left) and their corresponding patient group of origin (right). b, tSNE plots showing expression of marker genes for SMC subsets defined in panel a. c, Box and whisker plots showing the fraction of SMC originating from 4 groups in each cluster, with plot center, box and whiskers corresponding to median, IQR and 1.5 × IQR, respectively (MASC adjusted by Benjamini–Hochberg procedure; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; Supplementary Table 2). d, Violin plots of the expression levels of selected genes in SMCs among control and CRS subtypes (MAST with RE adjusted by Benjamini–Hochberg procedure; full list of P value given in Supplementary Table 4). e, tSNE plots displaying 8,715 endothelial cells from 21 individuals (5 healthy controls, 5 CRSsNP, 5 neCRSwNP, and 6 eCRSwNP patients) separated into 5 subsets (left) and their corresponding patient group of origin (right). f, tSNE plots showing expression of marker genes for endothelial subsets defined in panel e. g, Box and whisker plots showing the fraction of endothelial cells originating from 4 groups in each cluster, with plot center, box and whiskers corresponding to median, IQR and 1.5 × IQR, respectively (MASC adjusted by Benjamini–Hochberg procedure; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; Supplementary Table 2). h, Violin plots of the expression levels of selected genes in endothelial cells among control and CRS subtypes (MAST with RE adjusted by Benjamini–Hochberg procedure; full list of P value given in Supplementary Table 4). i, Violin plot showing the expression levels of PLAT in 8 major cell types of nasal mucosa. All panels depict the same number of cells and individuals described in panel a or e.