Extended Data Fig. 3: NUDT21 is co-expressed with CD19 mRNA across healthy and B-ALL bone marrow cells. | Nature Immunology

Extended Data Fig. 3: NUDT21 is co-expressed with CD19 mRNA across healthy and B-ALL bone marrow cells.

From: NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia

Extended Data Fig. 3

(a) Heatmap representation of cell type (row) z-score normalization of UMI counts for each individual CD19 candidate using healthy bone marrow scRNA-seq data. Genes ranked in descending order or individual candidate z-score across Prog_B 2 column. (b) UMAP representation of NUDT21 and CD19 mRNA expression as measured by log normalized UMI counts. (c) Scatterplot showing correlation between NUDT21 and CD19 mRNA levels (UMI count) across Prog_B 1, Prog_B 2, Naïve B and Memory B cells in healthy bone marrow scRNA-seq data. r- and p-values calculated on the basis of Pearson’s correlation.

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