Extended Data Fig. 4: Sub-genome screens.
From: In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
a, Pre-ranked GSEA of enriched and depleted sub-genome screen hits in the corresponding genome screen. Gene sets in sub-genome screens were defined with FDR < 0.25 threshold separately for enriched and depleted genes, and GSEA enrichment was performed by ranking genes by signed STARS score in the genome screen. Significance was assessed by the GSEA algorithm permutation test. b, Genes ranked by ICB vs NSG normalized fold change with circle size corresponding to -log10 FDR. The top genes with FDR < 0.25 at each end are listed and arranged by statistical significance.
