Extended Data Fig. 1: Overlap in differentially expressed genes/modules and kinetics of common module clusters. | Nature Immunology

Extended Data Fig. 1: Overlap in differentially expressed genes/modules and kinetics of common module clusters.

From: Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

Extended Data Fig. 1

a, b) Histograms of overlap in DEGs (A) or differentially expressed modules (B) between vaccines. A gene/module is shared with another vaccine if it is significantly (FDR < 0.05) regulated in the same direction, irrespective of timepoint. Blue bars, number of genesets shared (y-axis) between the same number of vaccines (x-axis). Grey bars represent the null distribution generated by n = 10,000 permutations of gene/module labels within vaccine + timepoint groups. Data are presented as mean values + /− 95% confidence interval. c) Kinetics of the mean FC of cluster 2 BTMs across vaccines. d) Kinetics of the mean FC of cluster 4 modules across vaccines.

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