Extended Data Fig. 2: Gene-level correlations between vaccines and estimated cell frequencies. | Nature Immunology

Extended Data Fig. 2: Gene-level correlations between vaccines and estimated cell frequencies.

From: Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

Extended Data Fig. 2

a) Correlation matrix of pairwise Spearman correlations of Day 3 gene-level fold changes between vaccines. b) Correlation matrix of pairwise Spearman correlations of Day 7 gene-level fold changes between vaccines. c) Scatterplot of Day 1 gene FCs between HIV and Malaria vaccines. d) Scatterplot of Day 1 gene FCs between Yellow Fever and Pneumococcus vaccines. e) Boxplot of Day 1 FC in xCell31 estimated B cell frequencies across vaccines. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range. Ebola (RVV): n = 11, HIV (RVV): n = 10, Influenza (IN): n = 298, Malaria (RP): n = 42, Pneumococcus (PS): n = 12, Varicella Zoster (LA): n = 31, Yellow Fever (LA): n = 11. f-g) Kinetics of the mean FC of modules (F) M47.0 and (G) M75 across YF vaccine studies. In C-D, correlation coefficient and p value determined via Pearson correlation. In E, statistical differences were determined via two-sided paired Student’s t-tests within each study and integrating p values across studies within each vaccine using Stouffer’s method (see Methods for further details). *p < 0.05, **p < 0.01, ***p < 0.001, **** p < 0.0001.

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