Fig. 4: GC B cells are expanded in adenoids after COVID-19.
From: Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children
a–d, Unsupervised clustering of CD19+ B cells from adenoids and tonsils (a) and PBMCs (c) according to flow cytometric surface markers. Quantification of the effect of previous SARS-CoV-2 infection on CD19+ B cell clusters in adenoids and tonsils (b) and PBMCs (d) showing regression coefficients ± 95% confidence intervals (CI) and P values, estimated with a linear model controlling for age and sex. Significantly different clusters (P < 0.05) between post-COV and UC groups are indicated with a star or highlighted in red. Adenoids, post-COV n = 11; UC n = 33; tonsils, post-COV n = 15; UC n = 42; PBMC, post-COV n = 14; UC n = 36. e, Frequency of CD127+ B cells in post-COV (n = 16) and UC (n = 41) PBMCs, P = 0.006. Significance calculated with two-sided Mann–Whitney U-test. Each symbol represents one donor. Mean ± s.d. are displayed. **P < 0.01.
