Extended Data Fig. 3: Related to Fig. 2: Higher intensity TCR stimulation amplifies age-associated chromatin accessibility differences seen at baseline or with low intensity stimulation. | Nature Immunology

Extended Data Fig. 3: Related to Fig. 2: Higher intensity TCR stimulation amplifies age-associated chromatin accessibility differences seen at baseline or with low intensity stimulation.

From: Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses

Extended Data Fig. 3

Peak sets from ATAC-seq analysis of naive CD4+ T cells from young (left) or old (right) adults were compared for each of the three conditions, unstimulated and after TCR stimulation with beads coated with low and medium concentrations of anti-CD3. Comparisons were done by robust empirical Bayes moderated statistical test; a Benjamini–Hochberg adjusted P value of 0.05 was used as cutoff. Relationships between the three sets of differential peaks are shown as Venn diagrams.

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