Extended Data Fig. 4: Related to Fig. 2c, d: Activation-induced temporal patterns of epigenetic changes in naive CD4+ T cells from young and older adults. | Nature Immunology

Extended Data Fig. 4: Related to Fig. 2c, d: Activation-induced temporal patterns of epigenetic changes in naive CD4+ T cells from young and older adults.

From: Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses

Extended Data Fig. 4

a, Genes assigned to differentially accessible regulatory sites were examined for significant enrichment in biological pathways. Selected GO terms associated with the different temporal patterns in young (upper panel) and older adults (lower panel) are shown. Comparisons were done by two-sided robust empirical Bayes moderated statistical test; a Benjamini–Hochberg adjusted P value of 0.05 was used as cutoff. b, Gene expression of indicated TFs shown as mean + s.e.m. n = 8 biologically independent samples.

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