Extended Data Fig. 2: Chronic TGFβ1 and TCR signals establish a stable dysfunctional program in CD8+ T cells. | Nature Immunology

Extended Data Fig. 2: Chronic TGFβ1 and TCR signals establish a stable dysfunctional program in CD8+ T cells.

From: Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Extended Data Fig. 2

(a) Summary bar graphs showing MFI of IFNG, (b) T-bet, (c) TNFα, and (d) CD107a in IFNG + CD8+ T cells after 7 days of resting from chronic or acute stimulation (day 35) as show in Fig. 2a. (e) Bar graphs showing MFI of TNFα, and (f) CD107a in IFNG + CD8+ T cells after 14 days of rest (say 42). (g) Bar graphs showing MFI of GZMB, and (h) CD11a in CD8+ T cells after 14 days of rest (Day 42). N = 3 biological replicates per group, representative of 2–3 independent experiments. Adjusted P-value ** p < 0.01, *** p < 0.001, **** p < 0.0001 comparisons were made using one-way ANOVA with Bonferroni’s multiple comparisons relative to Dysf. group. Error bars = mean ± SEM.

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