Extended Data Fig. 6: BMP4 agonist treatment promotes transcriptional recovery of effector and memory programs. | Nature Immunology

Extended Data Fig. 6: BMP4 agonist treatment promotes transcriptional recovery of effector and memory programs.

From: Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Extended Data Fig. 6

(a) Venn diagram of overlapping genes that are downregulated in Dysf. versus Treated.I-III CD8+ T cells on day 28. (b) Pathway enrichment analysis of genes that are upregulated in Treated.II versus Dysf. CD8+ T cells or overlap with the upregulated genes in Treated.III versus Dysf. CD8+ T cells (NCI-Nature 2016 pathway database). Significance was determined by Enrichr62. (c) Venn diagram of overlapping genes upregulated in Dysf. versus Treated.I-III CD8+ T cells. (d) Gene set enrichment analysis of biological pathways linked to the upregulated genes in Dysf. versus Treated.I-III CD8+ T cells using Hallmark gene signature database. (e) Interaction plots from RNA-seq data showing average expression levels of KLF3, (f) S1PR1, (g) GZMK, (h) FCGR3A, (i) TGFBR3, (j) CX3CR1, (k) PRF1, (l) CD28, (m) CD109, (n) MYO7A, (o) ITGAE, and (p) SMAD6 transcripts among chronically (Ch.TCR, Dysf., Treated.I-III) or acutely (Ac.TCR) stimulated CD8+ T cells on day 28.

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