Extended Data Fig. 7: TGFβ1 exposure drives transcriptional similarity to exhausted CD8+ T cells in human cancer. | Nature Immunology

Extended Data Fig. 7: TGFβ1 exposure drives transcriptional similarity to exhausted CD8+ T cells in human cancer.

From: Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Extended Data Fig. 7

(a) UMAP visualization of CD8+ T cell meta-clusters identified in single-cell RNA-seq analysis of human CD8+ T cell subsets including tumor-infiltrating lymphocytes (TILs) from 21 types of human cancer (GSE156728)45 (b, c) UMAP visualization showing RNA expression levels of some selected signature genes in human TILs and memory CD8+ T cell clusters that overlap with transcriptional features of in vitro-differentiated Dysfunctional and Treated human CD8+ T cells.

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