Extended Data Fig. 8: BMP signals maintain effector and memory programs in human CD8+ T cells. | Nature Immunology

Extended Data Fig. 8: BMP signals maintain effector and memory programs in human CD8+ T cells.

From: Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Extended Data Fig. 8

(a) Bar graph showing numbers of methylated (top) or demethylated (bottom) DMRs in Dysf. CD8+ T cells relative to all other conditions on day 28. (b) Venn diagrams showing transcription factor (TF)-binding motifs enriched in hypermethylated or (c) hypomethylated genomic regions in in Dysf. versus Treated.I, II, or III human CD8+ T cells on day 28. (d) Snapshots from scATAC-seq database (GSE129785) showing chromatin accessibility changes at selected loci of effector and memory, or (e) dysfunctional programs in human CD8+ T cell subsets from patients with cancer49.

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