Extended Data Fig. 1: Autocrine IL-1α production by Th17 cells enforces a pathogenic Th17 cell identity.
From: Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation
a, Th17 cells were stimulated with anti-CD3 and anti-CD28 mAbs for 5 days before intracellular cytokine staining and flow cytometry following PMA and ionomycin restimulation. Representative experiment. b, Cumulative data for (a). Two-sided paired t-test. c, ELISA of supernatants from Th17 cells stimulated for 5 days with anti-CD3 and anti-CD28 mAbs. Two-sided paired t-test.
