Signaling via T cell antigen receptors is diminished during aging. But paradoxically, CD4+ T cells from older adults tend to differentiate into effector-like rather than memory cells. An altered balance between the activities of HELIOS, IL-2Rα, and STAT5 influences this decision.
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Weinmann, A.S. Tipping the balance in CD4+ T cells. Nat Immunol 24, 8–9 (2023). https://doi.org/10.1038/s41590-022-01389-7
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DOI: https://doi.org/10.1038/s41590-022-01389-7
