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Neuroimmunology

Macrophages set the bar for acute pain sensitivity

Nature Immunology volume 24, pages 382–384 (2023)Cite this article

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A serendipitous behavioral observation in a mouse line led to the discovery that macrophages modulate acute pain. The macrophage-derived protein SNX25 sets the threshold for acute pain through tonic NGF signaling to cutaneous sensory neurons.

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Fig. 1: Macrophages contribute to nociception through different mechanisms at steady state or during inflammation.

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Acknowledgements

Supported by US National Institutes of Health (NIH) R35 NS105076 (C.J.W.) and NIH F31NS127357-01 (S.H.).

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Authors and Affiliations

  1. F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, USA

    Sara Hakim & Clifford J. Woolf

  2. Department of Neurobiology, Harvard Medical School, Boston, MA, USA

    Sara Hakim & Clifford J. Woolf

Authors
  1. Sara Hakim
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  2. Clifford J. Woolf
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Corresponding author

Correspondence to Clifford J. Woolf.

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Competing interests

C.J.W. is a founder of Nocion, Quralis and Blackbox Bio. S.H. declares no conflicts of interest.

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Hakim, S., Woolf, C.J. Macrophages set the bar for acute pain sensitivity. Nat Immunol 24, 382–384 (2023). https://doi.org/10.1038/s41590-023-01438-9

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