Extended Data Fig. 4: scWB scRNA-seq data substructure and concordance with transcriptomic sepsis response signature (SRS) endotypes.

a, First two principal components from principal components analysis of pseudobulked single-cell expression profiles of sepsis samples colored by SRS assignment. b, Pearson’s correlation of fold change in gene expression between SRS1 vs. non-SRS1 (sample level pseudobulks) in scWB and cohort in which SRS was originally derived⁵. c, Consensus clustering of pseudobulked single-cell gene expression profiles of sepsis samples (all cells per sample) at the level of two clusters. d, Overlaps of consensus clustering classification vs. SRS classification. e, Unsupervised hierarchical clustering of pseudobulked single-cell expression profiles of sepsis samples. SRS, sepsis response signature.