Extended Data Fig. 10: Working model depicting metabolic requirements in naïve and in activated B cells.
From: Distinct metabolic requirements regulate B cell activation and germinal center responses
Proposed model suggesting different metabolic constraints in B cells committed to either a T-dependent or a T-independent pathway for an optimal humoral response. LDHA-mediated glycolysis is essential for the early activation of B cells during a T-dependent GC response but is largely dispensable once the activated B cells are fully engaged in a GC reaction ('>' sign symbolizes 'greater than'). On the other hand, a T-independent extrafollicular response is not reliant on LDHA-mediated glycolysis.
