Fig. 6: Reintroducing RD restores mucosal and systemic immunity.
From: Short-term dietary changes can result in mucosal and systemic immune depression
a, Dietary intervention and immunization strategy. b, Quantification of footpad swelling of RD-fed and FD-fed mice during priming, 8 or 22 days after priming. c, Dietary intervention and immunization strategy. d, Quantification of footpad swelling of RD-fed and FD-fed mice (with or without C2 + C4 supplementation) during priming. e, Dietary intervention schematic. f, Frequencies of TH17 cells among CD3+CD4+ Tconv cells in PPs of RD-fed and FD-fed mice (with or without C2 + C4 supplementation). g, Dietary intervention and S. Typhimurium infection model. h, CFUs of S. Typhimurium in SI luminal content and liver in RD-fed and FD-fed mice (with or without C2 + C4 supplementation). i, Dietary intervention and S. Typhimurium infection model. j, CFUs of S. Typhimurium in SI luminal content and liver in RD-fed mice and mice switched to FD at different time points. Data in b are a pool of three experiments (n = 13 or 14). Data in d are a pool of three experiments (n = 13 or 16). Data in f are a pool of two experiments (n = 10 or 12). Data in h are a pool of four experiments (n = 13, 15 or 16). Data in j are a pool of two experiments (n = 7, 8 or 10). Data are shown as mean ± s.e.m. (b–f) or median (h–j). P values have been determined by two-tailed nonparametric Mann–Whitney U-test (b) or Kruskal–Wallis test with Dunn’s multiple comparison test (d,f,h,j).
