Extended Data Fig. 3: Tumor infiltrated NFAT5^KO P14 cells had superior anti-tumor potential compared to TI NFAT5^WT P14 cells in a co-transfer setting.

a) Timeline of the experiment: activated NFAT5^WT (CD45.1) and NFAT5^KO (CD45.2) P14 CD8⁺ T cells were co-transferred into B16-GP33⁻bearing CD45.1.2 mice. CD8⁺ TILs were analyzed 7 days post-ACT. b) Overlay of the GMFI of indicated proteins of NFAT5^WT and NFAT5^KO on the day of 1:1 transfer. c,d) Representative overlaid histograms of NFAT5^WT, NFAT5^KO P14, and endogenous CD8⁺ TILs of indicated proteins (up) with two-sided paired t-test comparison (below). Each pair of dots representing TILs analyzed from one mouse.

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