Extended Data Fig. 7: Motif enrichment analyses of trans-associated data. | Nature Immunology

Extended Data Fig. 7: Motif enrichment analyses of trans-associated data.

From: Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes

Extended Data Fig. 7

a, Left, HOMER known motif enrichment in BALB/cJ trans-regulated ATAC-seq peaks (y-axis) and C57BL/6J trans-regulated ATAC-seq peaks (x-axis). Right, view of highlighted region in left panel. b, Expression of selected transcription factors in C57BL/6J and BALB/cJ F0 Kupffer cells. * indicates differential expression with DESeq2 adjusted p-value < 0.05 (Wald’s test with multiple testing correction using Benjamini–Hochberg method) Exact p-values as follows: Fos 0.0017; Fosb 0.003; Jun 0.026; Junb 9.38e-9; Batf 0.047; Batf3 4.04e-10; Maf 8.15e-06; Nfkb1 0.004; Nfkb2 0.006; Rel 0.001; Relb 1.86e-6; Irf7 2.25e-5; Nr1h3 3.51e-7. c, Motif enrichment in ATAC-seq labeled enhancers associated with C57BL/6J and BALB/cJ trans genes.

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