Extended Data Fig. 9: Summary model. | Nature Immunology

Extended Data Fig. 9: Summary model.

From: Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes

Extended Data Fig. 9

Model of trans-regulated strain-specific Kupffer cell transcriptional networks. A majority of trans effects are controlled by the strain-specific cellular environment, while a smaller fraction of trans effects are driven by cell-intrinsic differences in pathway activity. Trans differences in pathway activity induce differential transcription factor activation and gene expression. Examples of strain-specific transcription factor motifs and downstream genes are shown for BALB/cJ and C57BL/6J Kupffer cells.

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