Extended Data Fig. 6: Single cell transcriptomic profiling reveals microglial apoE isoform-dependent pathways responding to amyloid pathology. | Nature Immunology

Extended Data Fig. 6: Single cell transcriptomic profiling reveals microglial apoE isoform-dependent pathways responding to amyloid pathology.

From: Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Extended Data Fig. 6

a, Feature plots showing the expression of selected markers in various microglial subtypes. Legend shows a color gradient of normalized expression. b, UMAP revealed an increased ARM4 (Cluster 9) cell population in mice with apoE3 expression in microglia. c, Percentage of cells from the APP/iE3/CreER/+ and APP/iE4/CreER/+ groups (Ctrl, n = 6; TAM-induced, n = 6) for each microglial cluster identified. Data represent mean ± s.e.m. **, P < 0.0001; N.S., not significant, two-tailed, t-test. The fold changes of cell numbers for each microglial cluster in TAM-induced mice compared with control mice (set as 1) are shown. d, Gene ontology (GO) enrichment analysis for genes in the Cluster 7 (ARM3) of the APP/iE3/CreER/+ mice. e, Gene ontology (GO) enrichment analysis for genes in the Cluster 7 (ARM3) of the APP/iE4/CreER/+ mice.

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