Extended Data Fig. 4: Comparison of transcriptional and epigenetic profiles of naive CD8 T cell subsets. | Nature Immunology

Extended Data Fig. 4: Comparison of transcriptional and epigenetic profiles of naive CD8 T cell subsets.

From: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Extended Data Fig. 4

(a) Heatmap of all differentially expression genes using Seurat’s FindAllMarkers function (parameters: logfc.threshold = 0.25, P < 0.05 determined by two-tailed Wilcoxon’s rank sum test) between CD8 T cell subsets in TEA-seq dataset. For visualization, values have been scaled (z-score) for each marker. (b–d) Transcription factor motif enrichment based on differentially accessible peaks between (b) true naive versus SCM, (c) true naive vs MNP-1, and (d) true naive versus MNP-2 CD8 T cell subsets. The adjusted pval of enrichment determined by hypergeometric testing.

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