Extended Data Fig. 6: TS and vaccine-expanded clonotypes. | Nature Immunology

Extended Data Fig. 6: TS and vaccine-expanded clonotypes.

From: Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19

Extended Data Fig. 6

Overlay of TRB sequences from CD69+CD137+ AIM-scTCRɑβ-seq of TS cells onto bulk TRB clonotype frequency at E01 and E03 in two representative participants. E01-to-E03 expanded (Ex) or contracted (Con), TRB clonotypes are shown, with TRB matching a CD69+CD137+ AIM-scTCRɑβ-seq (TS) shown in color and unmatched TRB are shown in gray (Und). Among clonotypes that neither expanded nor contracted (Non-Ex), only CD69+CD137+ AIM-scTCRɑβ-seq TRB-matched clonotypes are shown between red dashed lines. Frequencies of TRB clonotypes pre- and post-vaccine are as resolved by bulk TCR-β-seq. ND = not detected.

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