Fig. 3: Transcriptional changes to iron-homeostasis pathway genes in hospitalized patients with COVID-19. | Nature Immunology

Fig. 3: Transcriptional changes to iron-homeostasis pathway genes in hospitalized patients with COVID-19.

From: Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19

Fig. 3

a, Distribution of the log2-transformed fold change (FC) values across 324 measured genes with high-quality conserved IREs in their 3′ or 5′ untranslated region derived from the whole-blood transcriptome comparison of COVID-19 severity groups A–E at day 0–14 and HCs. Four genes of interest are annotated. b, Distribution of the log2(FC) across 60 measured genes in the iron-homeostasis gene set at day 0–14 (top) and heat map of gene-level detail for groups A–E versus HCs at day 0–14 (bottom). *P < 0.05, PFDR values from GSEA. c, Schematic of iron-homeostasis pathway (KEGG has04216) with genes colored according to the log2(FC) in group E at day 0–14. Genes corresponding to those shown in the heat map in b are annotated in blue text. d, Polynomial splines showing change in iron-homeostasis scores (PC1 from PCA of iron-homeostasis gene-set genes across all sampling time points for groups A–E). The gray band represents the IQR of the HCs. e, Spearman correlation between iron-homeostasis score and serum iron in groups C–E (scaled residuals following correction for time) at day 0–14, with points colored by severity group.

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