Extended Data Fig. 3: Acute neuronal loss is not affected by loss of RAGE or microglial LAIR-1. | Nature Immunology

Extended Data Fig. 3: Acute neuronal loss is not affected by loss of RAGE or microglial LAIR-1.

From: Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression

Extended Data Fig. 3

a) Decreased CA1 neurons in WT B6 (p = 0.0004) and RAGE KO mDNRAb+ (p < 0.0001) mice compared to their mDNRAb− counterparts (median (solid line) with quartiles (dash); n = 3-4 mice per group; n = 72-96 sections per group; two-tailed Kruskal-Wallis test). b) Decreased CA1 neurons in LAIR-1 cKO DNRAb+ mice compared to DNRAb− (median (solid line) with quartiles (dash); n = 3 mice per group; n = 67-98 sections per group; two-tailed Mann-Whitney test; p = 0.0394).

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