Extended Data Fig. 5: Concordance score of Ms4a7⁺ microglia with microglial gene signatures.

a) Higher DAM signature gene set score in Ms4a7⁺ compared with Homeostatic microglia (Keren-Shaul et al. (2017)³⁵ median (solid line) with quartiles (dash); n = 3 mice per group; n = 2515-15285 cells/cluster; two-tailed Mann-Whitney test; p < 0.0001). b) Lower Homeostatic signature gene set score in Homeostatic compared with Ms4a7⁺ cluster (Keren-Shaul et al.³⁵; median (solid line) with quartiles (dash); n = 3 mice per group; n = 2515-15285 cells/cluster; two-tailed Mann-Whitney test; p < 0.0001). c) Higher NPSLE signature gene set score in Ms4a7⁺ compared with Homeostatic microglia (Makinde et al.³⁸; median (solid line) with quartiles (dash); n = 3 mice per group; n = 2515-15285 cells/cluster; two-tailed Mann-Whitney test; p < 0.0001). d) Higher MGnD signature gene set score in Ms4a7⁺ compared with Homeostatic microglia (Krasemann et al.³⁹; median (solid line) with quartiles (dash); n = 3 mice per group; n = 2515-15285 cells/cluster; two-tailed Mann-Whitney test; p < 0.0001).