Extended Data Fig. 2: Associations with long COVID symptoms in full study cohort.

(a) Fibrinogen levels at 6 months were compared between pooled LC cases (n = 295) and Recovered (n = 233) and between the Cognitive group (n = 41) and Recovered (n = 233). Box plot centre line represent the Median and boundaries of the box represent interquartile range (IQR), the whisker length represents 1.5xIQR, any outliers beyond the whisker range are shown as individual dots. Median differences were compared using two-sided Wilcoxon signed-rank test *=p < 0·05, **=p < 0·01, ***=p < 0·001, ****=p < 0·0001. Unadjusted p-values are reported. b) Distribution of time from COVID-19 hospitalisation at sample collection applying CDC and NICE definitions of LC (n = 719) (c) Upset plot of symptom groups. Horizontal coloured bars represent the number of patients in each symptom group: Cardiorespiratory (Cardio_Resp), Fatigue, Cognitive, Gastrointestinal (GI) and Anxiety/Depression (Anx_Dep). Vertical black bars represent the number of patients in each symptom combination group. To prevent patient identification, where less than 5 patients belong to a combination group, this has been represented as ‘<5’. The Recovered group (n = 250) were used as controls. Forest plots show Olink protein concentrations (NPX) associated with (d) Cardio_Resp (n = 398), (e) Fatigue (n = 342), (f) Anx_Dep (n = 219), (g) GI (n = 134), and (h) Cognitive (n = 65). Error bars represent the median accuracy of the model.