Extended Data Fig. 6: Gene signatures of T cells neighboring mreg DCs and CXCL10+ macrophages. | Nature Immunology

Extended Data Fig. 6: Gene signatures of T cells neighboring mreg DCs and CXCL10+ macrophages.

From: Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy

Extended Data Fig. 6

Heatmap of gene expression of CD4 T cells, CD8 T cells, and Tregs, subdivided into three groups reflecting their neighborhood composition: adjacent to at least one LAMP3+CCL19+ mreg DC, adjacent to at least one CXCL10+ macrophage, or adjacent to neither. T cells adjacent to both were rare and thus not included in this analysis. Only genes significantly differentially overexpressed (GLMM adj. p < 0.05 & logFC > 0.5, see Methods) in one of the rows are shown.

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