Extended Data Fig. 9: Representative NanoString GeoMx regions of interest. | Nature Immunology

Extended Data Fig. 9: Representative NanoString GeoMx regions of interest.

From: Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy

Extended Data Fig. 9

(a) Fluorescently labeled RNA smFISH probes for CXCL10 and CCL19 on GeoMx slides guided region of interest (ROI) selection for transcriptional profiling. Histological features, region location, and number of regions profiled are noted. (b) Representative GeoMx images of stem-immunity (SI) hub, non-stem-immunity hub, and TLS ROI (as defined in (A)) for all five patients profiled using Nanostring GeoMx. White lines indicate ROI boundaries. ROI ID number for a given patient is indicated in the top left corner of each image.

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