Extended Data Fig. 1: Study overview.
From: JAK-STAT signaling maintains homeostasis in T cells and macrophages
Illustration of the study design and key results as a graphical abstract (a) and a summary table of transcriptome and epigenome alterations in JAK-STAT mutant cells (b). We hypothesized that baseline JAK-STAT signaling underlies immune cell homeostasis, beyond its well-established role during immune stimulation. We analyzed homeostatic JAK-STAT signaling through transcriptome and epigenome profiling in a large collection of JAK-STAT mutants and validated our results by depriving cells from their cellular context in ex vivo culture. Our molecular maps of homeostatic JAK-STAT signaling reveal substantial roles of JAK-STAT signaling in specific homeostatic JAK-STAT complexes and regulated gene modules.
