Extended Data Fig. 10: Hypothetical models of synergy. | Nature Immunology

Extended Data Fig. 10: Hypothetical models of synergy.

From: IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell responses

Extended Data Fig. 10

a, Experimental rationale for design of mixed bone marrow chimeras in Fig. 8h, with the null hypothesis being no synergy. b, Proposed model of positive feedback loop, summarizing sequencing results. Upper case protein names refer to protein function, lower case gene names refer to RNA sequencing data. ‘PROTEIN (Gene)’ refers to hypothetical regulatory links between transcription factors and target genes based on existing literature.

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