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Immunological tolerance

Nuclear squeezing wakes up dendritic cells

Dendritic cells migrate to and from lymph nodes in response to chemokine gradients.Data now show that steady-state migration of these cells can be triggered by a mechanosensitive pathway.

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Fig. 1: Dendritic cell trafficking in homeostasis and inflammation.

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Correspondence to Michael Sixt.

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Lembo, S., Sixt, M. Nuclear squeezing wakes up dendritic cells. Nat Immunol 25, 1131–1132 (2024). https://doi.org/10.1038/s41590-024-01881-2

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