Fig. 7: Vikala B cells do not have a statistically significant survival advantage to synergistic BCR–TLR9 stimulation.
From: A TNIP1-driven systemic autoimmune disorder with elevated IgG4
a–b, Representative flow cytometry plots (a) and proportions (b) of live purified WT B220+ B cells cultured from 8-week-old Tnip1+/+ (n = 1) mice with soluble or bead-conjugated IgM or CpG (ODN 1826) for 72 h; each dot represents a technical replicate. c,d, Representative flow cytometry plots (c) and proportions (d) of live B220+ B cells from 6–12-week-old Tnip1+/+ (n = 4) and Tnip1vik/vik (n = 4) mice cultured with bead-conjugated IgM or CpG (ODN 1826) for 72 h; each dot represents an individual mouse (biological replicate). Statistical significance was calculated using a two-way ANOVA with Šidák’s crrection for multiple comparisons. Exact P values are shown. In a–d, data are representative of n = 2 experiments.
