Extended Data Fig. 5: Targeting p97-Npl4 interaction did not disrupt immune homeostasis.
From: Targeting p97–Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity
a, Flow cytometry analysis showing the proportions of Treg cells (Foxp3+) and Th17 cells (IL17a+RORγt+) among CD4+ T cells in lungs from Vcp3A/3A, Foxp3Cre and Vcp3A/3A Foxp3Cre mice. b, Flow cytometry analysis showing the proportions of Treg cells (Foxp3+) and Th17 cells (IL17a+RORγt+) among CD4+ T cells in the colon from Vcp3A/3A, Foxp3Cre and Vcp3A/3A Foxp3Cre mice. c, The proportions of CD44hiCD62Llow subpopulation among the CD4+ or CD8+ T cells from spleens and lymph nodes of Vcp3A/3A, Foxp3Cre and Vcp3A/3A Foxp3Cre mice. n = 5 biologically independent samples examined over two independent experiments. d, Absolute numbers of Treg (Foxp3+) and Th17 cells (IL17a+) in draining lymph nodes (dLN) from Ctrl and TB-treated mice. n = 4 biologically independent samples examined over two independent experiments. e, Absolute numbers of Treg (Foxp3+) and Th17 cells (IL17a+) in lungs from Ctrl and TB-treated mice. n = 4 biologically independent samples examined over two independent experiments. f, Absolute numbers of Treg (Foxp3+) and Th17 cells (IL17a+) in colons from Ctrl and TB-treated mice. n = 4 biologically independent samples examined over two independent experiments. Data shown as means ± s.e.m. (c-f). Data were analyzed for significant differences by performing one-way ANOVA with Dunnett’s post hoc analysis (c–f).
