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Immunotherapy

CD45 threads the needle of cytokine cancer immunotherapy

Nature Immunology volume 25, pages 1775–1777 (2024)Cite this article

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Immunocytokines are cytokine-based fusion proteins with therapeutic potential. New CD45-targeted immunocytokines can reprogram systemic anti-tumor immunity by prolonged retention on T cells and dendritic cells while minimizing systemic toxicities through intratumoral delivery.

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Fig. 1: Dual anti-CD45–IL-12 and anti-CD45–IL-15 immunocytokine therapy.

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Authors and Affiliations

  1. Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Nils Wellhausen & Saar Gill

  2. Translational Center of Excellence in Hematopoietic Stem Cell Engineering, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

    Nils Wellhausen & Saar Gill

  3. Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Nils Wellhausen & Saar Gill

  4. Center for Cellular Therapy and Transplantation, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

    Saar Gill

Authors
  1. Nils Wellhausen
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  2. Saar Gill
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Correspondence to Saar Gill.

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The authors declare no competing interests.

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Wellhausen, N., Gill, S. CD45 threads the needle of cytokine cancer immunotherapy. Nat Immunol 25, 1775–1777 (2024). https://doi.org/10.1038/s41590-024-01956-0

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