Extended Data Fig. 6: An optimized Irf8 + 32 kb enhancer drives convergent differentiation of pre-cDC1 and pre-cDC2 toward a hybrid DC phenotype.
From: Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation
(a) Left panel: heatmap visualization of the bulk RNA-seq data as in Fig. 4e. Shown are the top 464 genes differentially expressed between WT cDC1 and cDC2 identified in Fig. 2f. Right panel: zoomed-in views of selected clusters. (b) Schematics illustrating the differentiation of CDP into cDC1, cDC2, and hybrid DC in WT, H/+, and H/H mice. Cell types are color-coded based on IRF8 and BATF3 expression.
