Extended Data Fig. 10: Schistosoma mansoni prevents the activation of MrgprA3 neurons that induce anti-helminth immunity by modulating cytokine expression patterns in myeloid APCs. | Nature Immunology

Extended Data Fig. 10: Schistosoma mansoni prevents the activation of MrgprA3 neurons that induce anti-helminth immunity by modulating cytokine expression patterns in myeloid APCs.

From: MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33

Extended Data Fig. 10

In sum, our data propose a model wherein the mammalian schistosome S. mansoni has evolved mechanisms to inhibit the activation of MrgprA3 neurons that promote anti-helminth resistance by re-programming of chromatin accessibility and transcriptional identity in cutaneous myeloid APCs through at least in part, by suppressing IL-33 expression, to rapidly unleash IL-17-mediated cutaneous inflammation. Created with BioRender.com.

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